During the reigns of Thutmose III and Amenhotep II, Rekhmire was the pharaoh's top administrator, the kingdom's second most influential post. Rekhmire also held several other titles, including steward of the Amen temple and governor of Thebes on the Nile's west bank. A French Egyptologist found his rock-cut burial chapel there in 1819. Because of its vast sequence of mural paintings representing Rekhmire's administrative tasks in addition to his death ceremonies, and because its inscriptions include a long text enumerating the duties of a vizier, the chapel is a significant source of knowledge about the New Kingdom.

The chapel has an upside-down T-shaped design typical of the 18th Dynasty, with the entrance at the large east end and a small 82-foot-long passage leading to a niche that previously housed portrait sculptures of Rekhmire and his wife. Paintings cover every wall surface and depict the vizier's administrative tasks, which included collecting taxes, administering justice, supervising royal artisans, and receiving tribute from foreign delegations. The murals in Rekhmire's tomb are the first documented depictions of the Minoans in Egyptian art.